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Published on: March 2, 2015
Serotonergic activity and the Beck Depression Inventory in the premenstrual syndrome
Yaprak Engin-Ustün1, Yusuf Ustün, Hakan Gürdal
1Department of Gynecology and Obstetrics, Medical Faculty, Ankara University, Ankara, Turkey. ustunyus@yahoo.com
Objective:
To investigate the relationship between platelet [3H]-imipramine binding and Beck Depression Inventory scores in the premenstrual syndrome (PMS).
Study Design:
Thirty-one patients with PMS and 26 healthy female volunteers participated in the study. Imipramine binding was measured by saturation binding of [3H]-imipramine. The Beck Depression Inventory form was completed.
Results:
The number of [3H]-imipramine binding sites (Bmax) was significantly lower in the study group (p = 0.003). Beck Depression Scores were significantly higher in the study group as compared with the control group (p = 0.001). No correlation was found between platelet [3H]-imipramine binding and Beck Depression Inventory scores (r = 0.100, p = 0.591).
Conclusion:
A significantly lower number of Bmax wasfound in patients with PMS as compared to controls, but no correlation between platelet [3H]-imipramine binding and Beck Depression Inventory scores was found.
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