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Reproduction and ulcerative colitis: a review.
Hen Y Sela1, Nathan Rojansky, Alon Y Hershko
1Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Ein- Kerem, Jerusalem, Israel. henys@hadassah.org.il
The Journal of Reproductive Medicine
|June 24, 2005
Summary
Ulcerative colitis (UC) generally does not impact fertility. However, active disease, surgery, or medication can affect reproduction, though most UC drugs are safe during pregnancy.
Area of Science:
- Gastroenterology
- Reproductive Medicine
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease with onset during peak reproductive years.
- Understanding UC's impact on fertility and pregnancy is crucial for affected women.
Purpose of the Study:
- To summarize current literature on ulcerative colitis, fertility, and pregnancy outcomes.
- To assess the effects of UC on reproductive health and pregnancy.
Main Methods:
- Systematic screening and summarization of English-language publications.
- Literature search conducted using Entrez-PubMed.
Main Results:
- Ulcerative colitis itself does not significantly impair fertility in women.
- Active disease, surgical history, and certain medications may negatively affect reproduction.
- Pregnancy outcomes in UC patients appear comparable to the general population, with similar exacerbation rates.
- Most medications used for UC are considered safe during pregnancy.
Conclusions:
- Ulcerative colitis management during pregnancy is vital for optimal outcomes.
- Maintaining disease control is paramount for pregnant individuals with UC.
- Further research may be needed to clarify specific pregnancy complications in UC.