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PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin

M B Butterworth1, R A Frizzell, J P Johnson

  • 1Dept. of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA. michael7@pitt.edu

American Journal of Physiology. Renal Physiology
|June 24, 2005
PubMed
Summary

Complexin protein regulates epithelial sodium channel (ENaC) trafficking in kidney cells. This protein stabilizes SNARE interactions, controlling ENaC insertion into the apical membrane and affecting sodium transport.

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