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Interaction of interleukin 2 and interleukin 4 during LAK cell generation
M Indrová1, T Jandlová, J Bubeník
1Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Folia Biologica
|January 1, 1992
Abstract:
Immunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation. The cytolytic effect of LAK cells activated for 3 days with IL-2 and measured by 51Cr release of three types of target cells, YAC-1 (NK-sensitive), C1498 (NK-resistant) and X63-Ag8.563 (plasmocytoma cell line utilized for insertion of the IL-2 and IL-4 genes), was significantly depressed by adding IL-4 during the activation period.