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Modulation of dendritic cell maturation and function by B lymphocytes.

Jagadeesh Bayry1, Sébastien Lacroix-Desmazes, Michel D Kazatchkine

  • 1The Edward Jenner Institute for Vaccine Research, Berkshire, United Kingdom. jagadeesh.bayry@jenner.ac.uk

Journal of Immunology (Baltimore, Md. : 1950)
|June 24, 2005
PubMed
Summary

B lymphocytes regulate dendritic cell (DC) function, impacting immune responses. Targeting B cells offers therapeutic strategies for autoimmune diseases and cancer immunotherapy.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial immune sentinels regulating immune responses.
  • B lymphocytes significantly influence DC function, both in vitro and in vivo.
  • DCs present antigens, initiating adaptive immunity.

Purpose of the Study:

  • To investigate the regulatory signals controlling dendritic cell function.
  • To elucidate the role of B lymphocytes in modulating dendritic cell activity.
  • To explore therapeutic applications targeting B cell-DC interactions.

Main Methods:

  • Review of accumulating evidence on B cell-DC interactions.
  • Analysis of cytokines, chemokines, and autoantibodies produced by B cells.
  • Examination of antigen presentation by DCs pulsed with immune complexes.

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Main Results:

  • B cells exert a profound regulatory effect on dendritic cell antigen-presenting function.
  • B cells produce key molecules (cytokines, chemokines, autoantibodies) influencing DC maturation, migration, and function.
  • DCs pulsed with immune complexes demonstrate efficient antigen cross-presentation.

Conclusions:

  • B cells are critical regulators of dendritic cell function and immune responses.
  • Targeting B cells offers a viable immunotherapeutic strategy for autoimmune and inflammatory conditions.
  • Utilizing DC cross-presentation of immune complexes presents an alternative approach for cancer and infectious disease immunotherapy.