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[Left ventricular function in chronic obstructive lung disease (author's transl)].

C Gabinski, G Courty, P Besse

    Bulletin Europeen De Physiopathologie Respiratoire
    |September 1, 1979
    PubMed
    Summary
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    Chronic obstructive lung disease patients show impaired left ventricular function, likely due to hypoxia and hypertrophy, not right heart failure. Ventricular kinetics are preserved despite altered contractility and compliance.

    Area of Science:

    • Cardiology
    • Pulmonology
    • Physiology

    Context:

    • Chronic obstructive lung disease (COPD) is associated with cardiovascular complications.
    • Hypoxia and cor pulmonale are common in COPD patients.
    • Left ventricular (LV) function in COPD requires further elucidation.

    Purpose:

    • To assess left ventricular function at rest and during post-extrasystolic potentiation in COPD patients.
    • To differentiate LV dysfunction causes in COPD with and without cor pulmonale.
    • To evaluate the relationship between right and left ventricular function in COPD.

    Summary:

    • 18 COPD patients (12 without cor pulmonale, 6 with) underwent LV function assessment.
    • LV dysfunction was present, characterized by hypertrophy and altered isovolumetric contractility, despite preserved ejection fraction and VCF.

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  • Abnormal LV compliance resulted from biventricular hypertrophy and septal motion, impacting diastolic function and decreasing LV output.

    • Impact:

    • Right heart failure in cor pulmonale is not secondary to left ventricular failure.
    • LV dysfunction in COPD is multifactorial, influenced by hypoxia, hypercapnia, LV hypertrophy, and extrinsic factors like right ventricular hypertrophy.
    • Findings highlight the complex interplay between lung and heart disease in COPD.