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Updated: Aug 17, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization
Stephen J Shuttleworth1, Richard V Connors, Jiasheng Fu
1Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94404, USA. Stephen.Shuttleworth@piramed.com
Abstract:
This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
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