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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Published on: August 12, 2017

B cell tolerance: lessons from transplantation

Marilia Cascalho1

  • 1Mayo Clinic College of Medicine, 200 First Street SW, Medical Sciences 2-113, Rochester, MN 55905, USA. Cascalho.marilia@mayo.edu

Current Drug Targets. Cardiovascular & Haematological Disorders
|June 25, 2005
PubMed

Given the ability of the B cell compartment to acquire tolerance to self we cannot explain why spontaneous humoral tolerance does not arise following transplantation. Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation.

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