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Estimating viral concentrations from dilution counts: an improved HP48SX version of the 'MLE2' program
1IMEC, Department MAP/ARS, Heverlee, Belgium.
Journal of Virological Methods
|May 1, 1992
Summary
The HP41C MLE2 program was translated for the HP48SX calculator due to the former's market withdrawal. The new version offers enhanced accuracy and easier data transfer for particle concentration analysis.
Area of Science:
- Scientific Computing
- Instrumentation
Background:
- The HP41C calculator's market withdrawal necessitated updating the 'MLE2' program.
- The HP41CV emulator for HP48SX does not support synthetic HP41C instructions, preventing direct program use.
Purpose of the Study:
- To translate the HP41C 'MLE2' program to the HP48SX platform.
- To leverage the HP48SX's superior accuracy and interfacing capabilities for scientific analysis.
Main Methods:
- Implementation of the 'MLE2' algorithm on the HP48SX.
- Utilizing HP48SX built-in functions (UTPC, UTPF, UTPN) for enhanced accuracy.
- Developing ASCII text output for algorithm results.
Main Results:
- A functional HP48SX version of the 'MLE2' program was created.
- The particle concentration (lambda) distribution was identified as chi-squared.
- Exact confidence bounds for lambda can now be computed using HP48SX commands.
Conclusions:
- The HP48SX provides a viable and improved platform for the 'MLE2' program.
- The chi-squared distribution allows for precise confidence interval calculation of particle concentration.
- The new implementation facilitates straightforward data transfer and reporting.