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Updated: Aug 10, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Magnetic resonance imaging: implication in acute ischemic stroke management

Oraporn Sitburana1, Walter J Koroshetz

  • 1Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622, USA.

Current Atherosclerosis Reports
|June 25, 2005
PubMed

Insights

Multimodality magnetic resonance imaging (MRI) techniques rapidly assess acute stroke, identifying salvageable brain tissue. This allows for extended treatment windows, improving patient outcomes by focusing on tissue at risk rather than just time.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Acute stroke management relies on rapid assessment of brain tissue viability.
  • Identifying the ischemic penumbra is crucial for timely intervention.

Purpose of the Study:

  • To highlight the role of multimodality MRI in acute stroke assessment.
  • To demonstrate how MRI techniques guide treatment decisions and extend therapeutic windows.

Main Methods:

  • Utilizing diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) for mismatch detection.
  • Employing fluid-attenuated inversion recovery (FLAIR), T2 susceptibility imaging, and magnetic resonance angiography (MRA).
  • Assessing tissue perfusion and vascular localization.

Main Results:

  • Multimodality MRI provides rapid, accurate information on ischemic penumbra and perfusion.
  • DWI/PWI mismatch identifies tissue at risk for salvage.
  • MRI facilitates patient selection for thrombolysis and neuroprotection.

Conclusions:

  • Multimodality MRI is essential for acute stroke patient management.
  • MRI-based treatment decisions can extend therapeutic timing beyond traditional windows.
  • These techniques aid in understanding cerebral ischemia pathophysiology.

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