Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological correlates of cognitive functioning in an elderly population.

C E Wright1, S R Kunz-Ebrecht, S Iliffe

  • 1Psychobiology Group, Department of Epidemiology and Public Health, University College London, UK. c.e.wright@ucl.ac.uk

Psychoneuroendocrinology
|June 25, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can social prescribing reach patients most in need? Patterns of (in)equalities in referrals in a representative cohort of older adults in England.

Perspectives in public health·2025
Same author

Dynapenic Abdominal Obesity as a Risk Factor for Metabolic Syndrome in Individual 50 Years of Age or Older: English Longitudinal Study of Ageing.

The journal of nutrition, health & aging·2023
Same author

The role of loneliness in the association between chronic physical illness and depressive symptoms among older adults: A prospective cohort study.

Journal of affective disorders·2023
Same author

Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study.

The journal of prevention of Alzheimer's disease·2022
Same author

Ophthalmology and Otology.

The Southern medical record·2022
Same author

The role of cognitive and social leisure activities in dementia risk: assessing longitudinal associations of modifiable and non-modifiable risk factors.

Epidemiology and psychiatric sciences·2022

Memory decline in older adults is linked to neuroendocrine and cardiovascular issues. Better memory correlates with healthier cortisol responses and faster heart rate recovery after tasks.

Area of Science:

  • Gerontology
  • Neuroendocrinology
  • Cardiovascular Physiology

Background:

  • Cognitive decline in aging is not inevitable, with potential links to neuroendocrine function.
  • The role of other physiological processes, like cardiovascular responses, in age-related memory impairment remains unclear.

Purpose of the Study:

  • To investigate the relationship between memory performance in older adults and the dysregulation of neuroendocrine and cardiovascular responses.
  • To determine if cortisol levels and cardiovascular recovery impact declarative memory and fluid intelligence in the elderly.

Main Methods:

  • Recruited 139 participants aged 65-80 years.
  • Administered verbal paired-associates recall tasks for declarative memory and a matrix reasoning task for fluid intelligence.

Related Experiment Videos

  • Collected salivary cortisol samples and measured blood pressure and heart rate before, during, and after tasks.

    • Main Results:

    • Cortisol responses were inversely related to memory performance after adjusting for covariates.
    • Superior memory was associated with faster post-task heart rate recovery in both sexes and diastolic blood pressure recovery in men.
    • These cardiovascular effects were independent of task performance and subjective stress ratings.

    Conclusions:

    • Memory function in the elderly is associated with both hypothalamic-pituitary-adrenocortical (HPA) axis function and cardiovascular regulation.
    • Dysregulation in neuroendocrine and hemodynamic function may increase vulnerability to cognitive decline in older adults.