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Related Experiment Videos

ACT: the Artemis Comparison Tool.

Tim J Carver1, Kim M Rutherford, Matthew Berriman

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. artemis@sanger.ac.uk

Bioinformatics (Oxford, England)
|June 25, 2005
PubMed
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The Artemis Comparison Tool (ACT) provides interactive genome sequence visualization and comparison. This open-source Java software identifies similarities, insertions, and rearrangements across complete genomes.

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Genome sequencing projects generate vast amounts of data.
  • Comparing complete genome sequences is crucial for understanding evolution and function.
  • Existing tools may lack comprehensive visualization or comparative analysis capabilities.

Purpose of the Study:

  • To introduce the Artemis Comparison Tool (ACT) for interactive genome sequence comparison.
  • To enable detailed analysis of genomic similarities, insertions, and rearrangements.
  • To provide a user-friendly, open-source platform for genomic data visualization.

Main Methods:

  • Utilizes BLASTN, TBLASTX, and Mummer for DNA sequence comparisons.
  • Employs reciprocal FASTA comparison for protein orthologue analysis.

Related Experiment Videos

  • Integrates Artemis components for sequence display and analysis.

    • Main Results:

    • ACT facilitates interactive visualization of complete genome sequence comparisons.
    • Identifies regions of similarity, insertions, and rearrangements at various scales.
    • Leverages powerful Artemis searching and analysis tools.

    Conclusions:

    • ACT is a versatile, open-source tool for comprehensive genome analysis.
    • Its Java-based, cross-platform compatibility enhances accessibility.
    • ACT supports detailed comparative genomics research.