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Updated: Aug 17, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Chest tube suction-associated unilateral negative pressure pulmonary edema in a lung transplant patient
Stavros G Memtsoudis1, Peter Rosenberger, Nicholas Sadovnikoff
1Department of Anesthesiology, Perioperative and Pain Medicine, Division of Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. smemtsoudis@partners.org
Abstract:
We describe a 29-yr-old male, status post-bilateral lung transplant, who developed unilateral negative pressure pulmonary edema induced by chest tube suction in association with bilateral bronchial anastomotic strictures. We conclude that negative pressure pulmonary edema may occur secondary to high levels of negative pressure applied to the intrapleural space via chest tubes in the presence of partial large airway obstruction. Post-lung transplant patients may be especially at risk because of compromised lymphatic drainage.
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