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[New tools for preclinical pharmaceutic research].

A Tartar1

  • 1Faculté de pharmacie de Lille, rue du Professeur Laguesse, F59045 Lille Cedex.

Annales Pharmaceutiques Francaises
|June 25, 2005
PubMed
Summary

Drug discovery faces declining success despite increased investment. Advances in pharmacogenomics and high-throughput screening accelerate early stages, but optimizing compounds for market remains challenging.

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Area of Science:

  • Pharmacogenomics and drug discovery
  • Structural biology in pharmaceutical research

Background:

  • Pharmaceutical research expenditures have doubled in ten years, yet the number of new marketed drugs has declined.
  • Despite methodological advances, the path from initial screening to a marketed drug is lengthy and complex.

Framework:

  • High-throughput screening of compound banks is the initial step in drug discovery.
  • Multidimensional optimization is required to refine compound properties like solubility, permeability, and safety.

Implementation:

  • Advances in pharmacogenomics, pharamcogenetics, high-throughput screening, and structural biology are key.
  • Development of cost-effective in vitro tests aids in predicting compound properties.

Implications:

  • In vitro tests facilitate prediction of drug properties, reducing reliance on animal testing.
  • Easily interpreted in vitro assays streamline the multidisciplinary drug optimization process.

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