Bmi1 in development and tumorigenesis of the central nervous system
Olga Shakhova1, Carly Leung, Silvia Marino
1Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
Journal of Molecular Medicine (Berlin, Germany)
|June 25, 2005
Abstract:
The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.
