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[Changes of endogenous ouabain in rat serum and certain tissues after exposure to simulated weightlessness]
Zhao-xia Liu1, Guang-dao Gao, Yong-jie Hu
1Department of Medicine, Xi'an Jiaotong University, Xi'an Shannxi, China. liuzx918@sohu.com
Objective:
To investigate the changes of endogenous ouabain (EO) in rat serum and some tissues after exposure to simulated weightlessness and to investigate its possible pathophysiology.
Method:
Male Wistar rats were randomly divided into control group (Con) and 1 week tail-suspension group (TS). Enzyme-linked immunosorbent assay (ELISA) was used to detect the content of EO in serum, hypothalamus, pituitary, adrenal gland, kidney, heart and liver.
Result:
Compared with Con, EO increased significantly in serum, hypothalamus, adrenal gland and kidney after tail suspension (P<0.05).
Conclusion:
Simulated weightlessness induced changes of EO in serum and some tissues, which may have some effects on the regulation of hydro-electrolyte metabolism and cardiovascular functions.
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