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Updated: Jul 29, 2026

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations
11:52

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations

Published on: August 4, 2016

Gene expression-driven diagnostics and pharmacogenomics in cancer

Yixin Wang1

  • 1Veridex LLC, a Johnson & Johnson Company, 3210 Merryfield Row, San Diego, CA 92121, USA. ywang44@vrxus.jnj.com

Current Opinion in Molecular Therapeutics
|June 28, 2005
PubMed

Insights

Microarray technology analyzes gene expression in tumors, aiding cancer classification and treatment. Standardization and validation are crucial for its clinical use in personalized oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Microarray technology enables gene expression profiling of human tumors.
  • Gene expression signatures are identified for tumor classification, prognosis, and therapy response.
  • This technology can elucidate therapeutic mechanisms of action.

Purpose of the Study:

  • To review studies on gene expression profiling for clinical applications.
  • To highlight the potential of microarrays in supporting disease prognosis and therapy decisions.
  • To discuss requirements for routine clinical implementation of microarrays.

Main Methods:

  • Gene expression profiling using microarray technology.
  • Analysis of clinically relevant tissue samples.
  • Review of existing literature on microarray applications in oncology.

Main Results:

  • Identification of gene expression patterns linked to tumor characteristics.
  • Demonstration of microarrays' utility in predicting treatment outcomes.
  • Highlighting the need for standardization and validation for clinical adoption.

Conclusions:

  • Microarray-based gene expression profiling is a powerful tool in oncology.
  • Standardization of techniques and extensive validation are essential for clinical integration.
  • Further research is needed to fully realize the potential of microarrays in personalized cancer care.

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