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Immunisation in the current management of cystic fibrosis patients

Anne Malfroot1, Georgios Adam, Oana Ciofu

  • 1Department of Paediatrics, Paediatric Respiratory Medicine, Infectious Diseases and Cystic Fibrosis Clinic, Academisch Ziekenhuis-Vrije Universiteit Brussel (AZ-VUB), Laarbeeklaan 101, B-1090 Brussels, Belgium. anne.malfroot@az.vub.ac.be

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|June 28, 2005
PubMed

Insights

Patients with cystic fibrosis (CF) should adhere to national immunization programs for optimal vaccine coverage. Vaccinations against hepatitis A and B, varicella, influenza, and pneumococcal disease are recommended for individuals with CF.

Area of Science:

  • Immunology
  • Pulmonology
  • Public Health

Background:

  • Cystic Fibrosis (CF) patients may have suboptimal vaccination coverage due to frequent hospitalizations and school absenteeism.
  • Individuals with CF are at increased risk for vaccine-preventable diseases throughout their lives.
  • There is a lack of uniform European immunization schedules for various vaccines in CF patients.

Purpose of the Study:

  • To review the literature on vaccination in patients with Cystic Fibrosis (CF) and other chronic diseases.
  • To provide recommendations for optimal vaccination strategies in CF.
  • To identify gaps in current vaccination guidelines for CF patients.

Main Methods:

  • Systematic literature review of vaccination in CF and chronic diseases.
  • Analysis of existing European and national immunization programs.
  • Evaluation of vaccine recommendations for specific diseases relevant to CF.

Main Results:

  • Hepatitis A and B vaccination is recommended for CF patients, similar to those with chronic liver disease.
  • Varicella vaccination is recommended for seronegative adolescents and transplant candidates due to potential pulmonary complications.
  • Annual influenza and general pneumococcal vaccination are indicated for CF patients.
  • RSV infection's role in CF requires further investigation, with no current vaccine available.

Conclusions:

  • CF patients benefit significantly from timely adherence to national immunization programs.
  • Specific recommendations for vaccines like Hepatitis A/B, Varicella, Influenza, and Pneumococcal are crucial for CF management.
  • Further research is needed to refine vaccination guidelines, particularly for adult CF patients and transplant candidates.

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