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Related Experiment Videos

Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study.

Antonio A Valente1, Euripedes C Miguel, Claudio C Castro

  • 1Department of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil.

Biological Psychiatry
|June 28, 2005
PubMed
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Voxel-based morphometry revealed distinct gray matter differences in obsessive-compulsive disorder (OCD) patients compared to controls. These findings highlight potential brain abnormalities in regions implicated in OCD pathophysiology.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Previous structural MRI studies on obsessive-compulsive disorder (OCD) yielded inconsistent results, potentially due to the regions-of-interest approach.
  • This study employed voxel-based morphometry (VBM) to investigate gray matter volume differences in OCD.

Purpose of the Study:

  • To assess gray matter volume differences in individuals with OCD compared to healthy volunteers.
  • To identify specific brain regions affected by OCD using an unbiased, whole-brain analysis.

Main Methods:

  • Structural magnetic resonance imaging (MRI) data were acquired from 19 OCD subjects and 15 healthy controls.
  • Images underwent spatial normalization and segmentation using optimized VBM.
  • Statistical comparisons were performed using the general linear model.

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Main Results:

  • Obsessive-compulsive disorder (OCD) subjects showed increased gray matter in posterior orbitofrontal and parahippocampal regions.
  • Decreased gray matter was observed in the left anterior cingulate cortex of OCD patients.
  • Obsessive-compulsive symptom severity correlated inversely with gray matter volume in the medial thalamus.

Conclusions:

  • Findings support previous research implicating orbitofrontal, cingulate, thalamic, and temporolimbic regions in OCD.
  • The study suggests that parietal cortex involvement in OCD pathophysiology requires further investigation.