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Published on: October 19, 2014
Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma
Maria Cristina Rapanotti1, Roberta Caruso, Sergio Bernardini
1Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Abstract:
Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.