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Updated: Aug 17, 2026

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
Published on: January 26, 2024
War is peace--dispatches from the bacterial and phage killing fields
André M Comeau1, Henry M Krisch
1Laboratoire de Microbiologie et Génétique Moléculaires, CNRS UMR-5100, 118 Route de Narbonne, 31062 Toulouse, Cedex, France.
Abstract:
Large-scale sequence analyses of phage and bacteria have provided new insights into the diverse and multifaceted interactions of these genomes. Such interactions are important because they determine the partitioning of a large fraction of global biomass. Furthermore, the struggle between phage and bacteria has had a significant impact on the evolution of the biosphere. This competition for resources has created an enormous pool of genetic diversity. Eons of horizontal genetic transfer have permitted the entire biosphere to directly benefit from a bargain-basement source of evolutionary innovation.
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