Relation between coronary artery calcium and incident chest pain in a community-dwelling screening population

Allen J Taylor1, Navin S Arora, Irwin Feuerstein

  • 1Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA. allen.tayor@na.amedd.army.mil

Insights

New chest pain is common in healthy individuals, even without heart disease indicators like coronary artery calcium. Doctors should assess chest pain based on overall risk, not just calcium scores.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Diagnostic Imaging

Background:

  • Chest pain is a frequent symptom prompting medical evaluation.
  • Coronary artery calcium (CAC) is a marker for coronary artery disease (CAD).
  • The role of CAC in evaluating new-onset chest pain in asymptomatic individuals requires clarification.

Purpose of the Study:

  • To investigate the incidence of new chest pain in an asymptomatic population.
  • To determine the association between coronary artery calcium and incident chest pain.
  • To inform clinical guidelines for chest pain evaluation in primary care.

Main Methods:

  • Prospective cohort study of 1,743 asymptomatic healthy men and women.
  • Follow-up duration of up to 4 years.
  • Assessment of incident chest pain and prevalence of coronary artery calcium via imaging.

Main Results:

  • Incident chest pain developed in 30.3% of participants over 4 years.
  • Coronary artery calcium prevalence was similar across groups with no chest pain, noncardiac pain, atypical pain, or cardiac chest pain.
  • No significant difference in CAC was observed based on chest pain characteristics.

Conclusions:

  • New-onset chest pain is a common occurrence in asymptomatic individuals.
  • Coronary artery calcium levels do not strongly differentiate types of chest pain in this population.
  • Chest pain evaluation should prioritize pretest probability of CAD over solely relying on CAC findings.

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