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Updated: Aug 17, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
Microsurgical laryngotracheal reconstruction
Ralph W Gilbert1, Peter C Neligan
1Department of Otolaryngology/Head and Neck Surgery, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario, Canada. ralph.gilbert@uhn.on.ca
Abstract:
Laryngotracheal reconstruction using free-tissue transfer represents one of the new challenges for the head and neck reconstructive surgeon. This article reviews the anatomy and physiology of the larynx and trachea and discusses the clinical context of laryngotracheal reconstruction, particularly with regard to malignant tumors involving the larynx and cervical trachea. It reviews the free-tissue reconstructive options, including the free forearm flap, the temporoparietal flap, and the two-staged procedure described by Delaere.
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