Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

COPII and exit from the endoplasmic reticulum.

Bor Luen Tang1, Ya Wang, Yan Shan Ong

  • 1Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore. bchtbl@nus.edu.sg

Biochimica Et Biophysica Acta
|June 28, 2005
PubMed
Summary

The vesicular coat protein II (COPII) complex facilitates essential endoplasmic reticulum (ER) to Golgi transport. Recent studies reveal complex cargo selection and vesicle formation, challenging classical models of ER export.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking primary cilia defects to the "Big 3" neurodegenerative diseases - causal, consequential, or correlative?

EXCLI journal·2026
Same author

Possible misplaced perception of moral shame in AI-use disclosure.

Accountability in research·2026
Same author

Letter to the Editor: Citations of Retracted Publications Should Be Discounted From One's Bibliometric Indicator.

Journal of Korean medical science·2026
Same author

Illuminating Clinical TEAD Inhibitors Through Structural Biology.

Journal of medicinal chemistry·2026
Same author

FRZB-induced anti-angiogenic effect via Caveolin-1-mediated TGFβ signalling.

Nature communications·2026
Same author

Discovery of Pan-TEAD Inhibitors That Disrupt YAP-TEAD Interaction as a Potential Therapy for Gastric Cancers and Mutant KRAS and EGFR Lung Cancers.

ACS medicinal chemistry letters·2026

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The vesicular coat protein II (COPII) complex is crucial for membrane trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus.
  • COPII mediates the formation and transport of vesicles, a fundamental process in eukaryotic cells.

Purpose of the Study:

  • To elucidate the structural and molecular mechanisms of COPII subunit assembly and cargo selection during ER export.
  • To investigate recent findings that challenge the classical model of ER-to-Golgi vesicle transport.

Main Methods:

  • Genetic analysis of yeast secretion mutants.
  • Structural, morphological, and molecular analyses of COPII complex.
  • Investigation of proteins that modulate COPII function.

Related Experiment Videos

Main Results:

  • Detailed understanding of COPII subunit assembly and selective cargo packaging.
  • Emerging data indicate a more complex picture of vesicle formation at ER exit sites (ERES) than previously thought.
  • Identification of proteins that regulate COPII-based cargo selection, vesicle formation, and targeting.

Conclusions:

  • COPII-mediated ER export is a highly complex and regulated process.
  • Recent research has significantly advanced our understanding of COPII function and its role in cellular transport.
  • The classical model of ER export requires revision based on new molecular insights.