Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple activities for Arf1 at the Golgi complex.

Julie G Donaldson1, Akira Honda, Roberto Weigert

  • 1Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA. jdonalds@helix.nih.gov

Biochimica Et Biophysica Acta
|June 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of extracorporeal shockwave therapy on the lumbar spine of osteoporotic rat models.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

27-Hydroxycholesterol in bile duct tissue promotes cholangiocarcinoma progression through estrogen receptor signaling.

American journal of cancer research·2026
Same author

Site-specific bidirectional regulation of <i>Fgf15</i> transcription in the mouse ileum.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same author

The Conjugated Bile Acids Profile Suggests a Novel Liver-Muscle Axis Associated With Sarcopenia in Chronic Liver Disease.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Spatially Distinct Myosin II Architectures Regulate Protrusion Dynamics and Directional Persistence during Immune Cell Migration.

bioRxiv : the preprint server for biology·2026
Same author

Intravital single-molecule imaging reveals cytoskeletal turnover as a driver of membrane remodeling in live animals.

bioRxiv : the preprint server for biology·2026
Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019
Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019
Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019
See all related articles

ADP-ribosylation factor (Arf) GTPases control Golgi apparatus membrane traffic and structure. Specific Arf regulators, spatially distributed on the Golgi, may direct coat protein recruitment for efficient protein transport.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • ADP-ribosylation factor (Arf) GTPases are key regulators of intracellular membrane traffic and organelle structure.
  • At the Golgi complex, Arfs orchestrate the recruitment of cytoplasmic coat proteins, modulate lipid composition via enzyme activity, and assemble cytoskeletal scaffolds.
  • Arf1 is the most extensively studied Arf family member regarding its Golgi functions.

Purpose of the Study:

  • To investigate the functional significance of the spatial distribution of Arf regulators within the Golgi complex.
  • To understand how localized Arf regulation contributes to the sorting and transport of membrane proteins.

Main Methods:

  • The abstract does not specify methods.
  • Further research would involve cell imaging and biochemical assays to study Arf protein localization and function.

Related Experiment Videos

Main Results:

  • Arf proteins are crucial for membrane traffic and organelle structure at the Golgi.
  • Regulators that activate and inactivate Arf1 are found in distinct Golgi regions.
  • This spatial arrangement of regulators may facilitate region-specific recruitment of coat proteins and Arf effectors.

Conclusions:

  • The spatial localization of Arf regulators on the Golgi complex is likely important for precise control of membrane traffic.
  • This organization may ensure the correct sorting and transport of proteins to different cellular destinations.