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Golgi structure in stress sensing and apoptosis
Stuart W Hicks1, Carolyn E Machamer
1Department of Cell Biology, Johns Hopkins University School of Medicine, 725 Wolfe St., Baltimore, MD 21205, United States.
Biochimica Et Biophysica Acta
|June 28, 2005
Summary
The Golgi complex, crucial for protein processing, may also sense and respond to cellular stress. Its intricate structure suggests a role beyond cargo transport, potentially initiating stress signaling or apoptosis.
Area of Science:
- Cell Biology
- Molecular Biology
- Organelle Function
Background:
- The Golgi complex in mammalian cells consists of stacked cisternal membranes forming a reticular network linked to the microtubule-organizing center.
- Its known role involves efficient processing and sorting of secretory cargo.
Purpose of the Study:
- To review experimental evidence suggesting novel functions of the Golgi complex.
- To explore the hypothesis that the Golgi's structure evolved for stress sensing and signal transduction.
Main Methods:
- Review of recent experimental findings.
- Analysis of the structural organization of the mammalian Golgi complex.
Main Results:
- The Golgi complex's organization suggests functions beyond cargo processing.
- Evidence indicates the Golgi may initiate signaling pathways to manage cellular stress.
Conclusions:
- The elaborate structure of the mammalian Golgi complex may have evolved to sense and transduce stress signals.
- The Golgi complex might play a role in cellular stress response and apoptosis initiation.