Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-particulate matter-health interactions.

Steven R Kleeberger1, Yoshinori Ohtsuka

  • 1Laboratory of Respiratory Biology, Environmental Genetics Group, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC 27705, USA. kleeber1@niehs.nih.gov

Toxicology and Applied Pharmacology
|June 28, 2005
PubMed
Summary

Genetic factors significantly influence how individuals respond to air pollution, impacting susceptibility to its harmful effects. Understanding these genetic variations is key to identifying at-risk populations and developing targeted health strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic labels and clusters based on oxygen requirements in preterm infants with chronic lung disease: a data-driven exploratory cluster analysis in two independent cohorts.

The Lancet. Child & adolescent health·2025
Same author

APOBEC3G Is a p53-Dependent Restriction Factor in Respiratory Syncytial Virus Infection of Human Cells Included in the p53/Immune Axis.

International journal of molecular sciences·2023
Same author

Vanadium Pentoxide Exposure Causes Strain-Dependent Changes in Mitochondrial DNA Heteroplasmy, Copy Number, and Lesions, but Not Nuclear DNA Lesions.

International journal of molecular sciences·2023
Same author

Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasia.

Scientific reports·2023
Same author

Relationship between disturbances of CO<sub>2</sub> homeostasis and force output characteristics during isometric knee extension.

Respiratory physiology & neurobiology·2023
Same author

Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program.

Clinical epigenetics·2022

Area of Science:

  • Environmental Health
  • Genetics
  • Toxicology

Background:

  • Individual responses to air pollutants vary, indicating heightened risk for certain subpopulations.
  • Susceptibility is influenced by extrinsic factors (e.g., prior exposure, nutrition) and intrinsic factors (e.g., age, gender, genetics).
  • Genetic background plays a crucial role in determining susceptibility to environmental pollutants.

Purpose of the Study:

  • To investigate the genetic factors contributing to differential susceptibility to air pollutants.
  • To explore the complex interactions between environmental exposures and genetic predispositions for disease risk and severity.

Main Methods:

  • Utilized traditional family-based linkage studies and positional cloning.
  • Employed case-control studies with candidate genes, quantitative analysis, and single nucleotide polymorphisms.

Related Experiment Videos

  • Conducted linkage analyses in genetically standardized animal models (mice).

    • Main Results:

    • Identified significant susceptibility quantitative trait loci on mouse chromosomes 1, 6, 11, and 17.
    • Comparative mapping between human and mouse genomes is yielding candidate susceptibility genes.
    • Mouse models have proven effective in identifying genetic determinants of pollutant response.

    Conclusions:

    • Genetic background is a critical determinant of individual susceptibility to air pollutants.
    • Integrating human studies with animal modeling provides valuable insights into genetic factors influencing pollutant response.
    • Further research using association studies in human subjects is warranted to validate candidate genes.