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Related Experiment Videos

Food hypersensitivity-immunologic (peripheral) or cognitive (central) sensitisation?

Arnold Berstad1, Gülen Arslan, Ragna Lind

  • 1Division of Gastroenterology, Institute of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. arnold.berstad@helse-bergen.no

Psychoneuroendocrinology
|June 28, 2005
PubMed
Summary

Patients with food hypersensitivity often experience unexplained symptoms, but their condition is typically non-allergic. Cognitive-emotional factors, not peripheral sensitization, may drive these food hypersensitivity disorders.

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Area of Science:

  • Gastroenterology and Immunology
  • Psychosomatic Medicine

Background:

  • Food hypersensitivity significantly impacts patient quality of life, causing unexplained abdominal and extra-abdominal symptoms.
  • Distinguishing food allergy from functional and organic disorders presents diagnostic challenges for healthcare providers.
  • Alternative medicine often gains traction due to perceived neglect and poor insight into these complex conditions.

Purpose of the Study:

  • To explore diagnostic methods for food hypersensitivity.
  • To investigate the underlying pathogenetic mechanisms of food hypersensitivity.
  • To propose an improved approach for managing patients with self-reported food hypersensitivity.

Main Methods:

  • Assessment of faecal calprotectin and gut permeability to rule out organic disease.

Related Experiment Videos

  • Evaluation of conventional provocation tests for diagnosing food hypersensitivity.
  • Development and preliminary assessment of a novel ultrasound provocation test.

    • Main Results:

    • Faecal calprotectin and gut permeability tests aid in excluding organic conditions.
    • Conventional provocation tests for food hypersensitivity are found to be cumbersome.
    • The majority of patients with self-reported food hypersensitivity exhibit non-allergic disorders.

    Conclusions:

    • Cognitive-emotional sensitization at the brain level, rather than peripheral immunological sensitization, is suggested as a primary mechanism in food hypersensitivity.
    • Peripheral sensory mechanisms may trigger cognitive network activation, often misidentified as 'food allergy'.
    • An interdisciplinary approach is recommended for managing patients presenting with food hypersensitivity.