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Updated: Aug 17, 2026

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
Treatment of Gorham's disease with zoledronic acid
M D Mignogna1, S Fedele, L Lo Russo
1Oral Medicine Division, Department of Odontostomatological and Maxillofacial Sciences, University Federico II of Naples, Via Pansini 5, 80129 Naples, Italy. mignogna@unina.it
Abstract:
Gorham's disease (GD) is a rare disorder characterized by spontaneous and progressive osteolysis of one or more bones and thought to belong to lymphangiomatoses spectrum of diseases. Surgical, radiation and medical therapies have been performed with variable and often discouraging outcomes and currently there is no recognized effective treatment. In this paper we describe a 24-year-old girl with GD localized to mandible who was effectively managed with zoledronic acid, a nitrogen-containing high-potency bisphosphonate.
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