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Published on: February 28, 2014
Single embryo transfer is an option in frozen embryo transfer
C Hydén-Granskog1, L Unkila-Kallio, M Halttunen
1Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland. christel.hyden-granskog@hus.fi
Background:
A good strategy to decrease multiple pregnancy rate in assisted reproduction technology (ART) is the use of single embryo transfer (SET).
Methods:
This retrospective study analysed 1647 frozen embryo transfers carried out during 1998-2003 in Helsinki University Central Hospital; of these, 872 were double embryo transfers (DETs) and 775 SETs. The SET group included 140 (18.1%) elective SETs (eSETs).
Results:
The yearly rate of SETs in frozen cycles increased from 28 to 66%. Overall, the clinical pregnancy rate per frozen embryo transfer was 30.7% and the delivery rate 22.6%. The delivery rate was significantly higher in DET cryocycles than in SET cryocycles (25.7 versus 19.2%, respectively; P < 0.01). In DET cryocycles, the multiple delivery rate was 21.9%, 10 times higher than that observed in cryocycles with SET (2.0%) (P < 0.0001). When eSET was applied, no difference in delivery rate was observed when compared with cryocycles with DET (28.6 and 25.7%, respectively).
Conclusions:
SET can be used in frozen cycles to reduce multiple delivery rates.
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