Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PROTINFO: new algorithms for enhanced protein structure predictions.

Ling-Hong Hung1, Shing-Chung Ngan, Tianyun Liu

  • 1Computational Genomics Group, Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Nucleic Acids Research
|June 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphical and interactive spatial proteomics image analysis workflow.

GigaByte (Hong Kong, China)·2026
Same author

Chromap Suite: an open-source single-binary platform for agentic multiomic RNA + ATAC profiling.

bioRxiv : the preprint server for biology·2026
Same author

Atrial fibrillation type-specific prediction of recurrence after catheter ablation: the pivotal role of right atrial remodeling revealed by explainable machine learning.

Frontiers in cardiovascular medicine·2026
Same author

Effect of occupational therapy on upper limb function and related rehabilitation outcomes after stroke: a systematic review and meta-analysis.

Frontiers in neurology·2026
Same author

Combining cutting edge computational and experimental methods for targeting KRAS mutations in non-small cell lung cancer.

Expert opinion on drug discovery·2026
Same author

A prospective observational study of lifestyle behaviors and biomarkers to promote cardiometabolic health in healthcare workers during the COVID-19 pandemic.

Frontiers in molecular biosciences·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

The PROTINFO web server offers new protein structure prediction tools. These modules accurately determine a protein's tertiary structure from its sequence, enhancing computational biology research.

Area of Science:

  • Computational biology
  • Structural bioinformatics
  • Biochemistry

Background:

  • Protein structure prediction is crucial for understanding biological function.
  • Accurate prediction of tertiary structure remains a significant challenge in bioinformatics.
  • Existing methods often require substantial computational resources or specialized expertise.

Purpose of the Study:

  • To introduce novel algorithms and modules for protein structure prediction.
  • To enhance the capabilities of the PROTINFO web server.
  • To provide an accessible tool for determining atomic coordinates of protein tertiary structures.

Main Methods:

  • Development of new comparative and de novo modeling modules.
  • Integration of improved back-end algorithms into the PROTINFO web server.

Related Experiment Videos

  • Rigorous evaluation of prediction accuracy through established benchmarks.

    • Main Results:

    • The new modules significantly improved protein structure prediction accuracy.
    • PROTINFO was recognized as a top-performing server at the Critical Assessment of Protein Structure Prediction (CASP) meeting.
    • The server successfully predicts atomic coordinates for protein tertiary structures from input sequences.

    Conclusions:

    • The PROTINFO web server provides a powerful and accurate tool for protein structure prediction.
    • The developed algorithms represent a significant advancement in the field.
    • The accessibility of the server facilitates research in structural biology and drug discovery.