The targets of CAPRI rounds 3-5

Ten protein-protein complexes have been offered by X-ray crystallographers as targets for structure prediction in Rounds 3-5 of the CAPRI experiment. They illustrate molecular recognition in several domains of biology: enzyme regulation, antigen-antibody recognition, signal transduction, and oligomer assembly. The targets presented various degrees of difficulty to the predictors, depending on their status (bound when components were taken from the complex, unbound when coming from independent structures of the free proteins), the amplitude of conformation changes, and the amount of biological information available. Predictors produced high-quality models of 6 of the targets, good models of 3 others, and failed only in 1 case, where the conformation change was particularly large. This result demonstrates significant progress relative to earlier rounds of CAPRI.