Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clostridial Rho-inhibiting protein toxins.

K Aktories1, I Just

  • 1Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104 Freiburg, Germany. klaus.aktories@pharmakol.uni-freiburg.de

Current Topics in Microbiology and Immunology
|June 29, 2005
PubMed
Summary

Rho proteins regulate cell functions and are targeted by bacterial toxins. This review covers Rho-inactivating toxins like large clostridial cytotoxins and C3-like transferases that modify Rho GTPases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptation of quality control pipeline for Skeletal Muscle 31P MR Spectroscopy at 3T and 7T.

Zeitschrift fur medizinische Physik·2026
Same author

Supplementation-induced change in muscle carnosine is paralleled by changes in muscle metabolism, protein glycation and reactive carbonyl species sequestering.

Physiological research·2022
Same author

Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells.

Scientific reports·2017
Same author

TNF-α induces dyscohesion of epithelial cells. Association with disassembly of actin filaments.

Endocrine·2010
Same author

Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2008
Same author

Large clostridial cytotoxins.

Reviews of physiology, biochemistry and pharmacology·2004

Area of Science:

  • Cell Biology
  • Microbiology

Background:

  • Rho proteins are critical regulators of fundamental cellular processes.
  • These GTPases control cell morphology, migration, polarity, transcription, and cell cycle.
  • Bacterial toxins and effectors target Rho GTPases, modulating their activity.

Purpose of the Study:

  • To review Rho-inactivating bacterial toxins and effectors.
  • To detail the mechanisms of Rho GTPase inactivation by specific bacterial protein families.

Main Methods:

  • Literature review of Rho-inactivating toxins.
  • Analysis of large clostridial cytotoxins and C3-like transferases.
  • Description of enzymatic inactivation mechanisms (glucosylation, ADP-ribosylation).

Main Results:

Related Experiment Videos

  • Identified large clostridial cytotoxins as a major class of Rho-inactivating toxins.
  • Highlighted C3-like transferases as another key family.
  • Detailed the distinct enzymatic mechanisms (glucosylation and ADP-ribosylation) employed by these toxins.

Conclusions:

  • Rho GTPases are key targets for bacterial virulence factors.
  • Large clostridial cytotoxins and C3-like transferases represent significant bacterial strategies to disrupt host cell functions via Rho inactivation.