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Updated: Aug 17, 2026

A Simple Fluorescence-based Reporter Assay to Identify Cellular Components Required for Ricin Toxin A Chain (RTA) Trafficking in Yeast
Published on: December 15, 2017
Clostridial Rho-inhibiting protein toxins
1Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104 Freiburg, Germany. klaus.aktories@pharmakol.uni-freiburg.de
Abstract:
Rho proteins are master regulators of a large array of cellular functions, including control of cell morphology, cell migration and polarity, transcriptional activation, and cell cycle progression. They are the eukaryotic targets of various bacterial protein toxins and effectors, which activate or inactivate the GTPases. Here Rho-inactivating toxins and effectors are reviewed, including the families of large clostridial cytotoxins and C3-like transferases, which inactivate Rho GTPases by glucosylation and ADP-ribosylation, respectively.
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