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Updated: Jul 10, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Selection of CD4+CD25+ regulatory T cells by self-peptides
C Cozzo1, M A Lerman, A Boesteanu
1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Abstract:
Regulatory T cells have been shown to prevent the development of autoimmune disease, and can modulate immune responses during infections or following tissue transplantation. Recently, the processes by which CD4+CD25+ regulatory T cells are produced during immune repertoire formation have begun to be elucidated. This review focuses on the role of self-peptides in mediating CD4+CD25+ regulatory T cell selection in the thymus. How self-peptides continue to have an important influence on the accumulation of CD4+CD25+ regulatory T cells in the periphery is also discussed.
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