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Updated: Aug 17, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Naturally arising CD25+CD4+ regulatory T cells in tumor immunity
1Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto 606-8507, Japan.
Abstract:
Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.
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