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Updated: Aug 17, 2026

A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
Published on: October 6, 2023
Metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease also decreases at thyroid
Hideaki Matsui1, Fukashi Udaka, Masaya Oda
1Department of Neurology, Sumitomo Hospital, Kitaku, Osaka, Japan. matsui-hideaki@sumitomo-hp.or.jp
Background:
Decreased cardiac metaiodobenzylguanidine (MIBG) uptake was reported in Parkinson's disease and this contributes to the differential diagnosis between Parkinson's disease and other forms of parkinsonism such as multiple system atrophy. However, decreased MIBG uptake of the thyroid has not been demonstrated.
Objective:
To compare MIBG uptake of the thyroid among Parkinson's disease, multiple system atrophy and controls.
Methods:
Twenty-six patients with Parkinson's disease, 11 patients with multiple system atrophy and 14 controls were examined in this study. Planar images were taken 15 minutes (early images) and 3 hours (late images) after intravenous injection of 111 MBq 123I-MIBG.
Results:
MIBG uptake of the thyroid on early images decreased significantly in Parkinson's disease compared to controls (p < 0.0001) and multiple system atrophy (p = 0.018). MIBG uptake of the thyroid on early images decreased significantly also in multiple system atrophy compared to controls (p = 0.027). On late images, thyroid uptake differed significantly only between Parkinson's disease and controls (p = 0.010).
Conclusions:
Our study is the first to demonstrate decreased MIBG uptake of the thyroid in Parkinson's disease. Sympathetic nervous denervation of Parkinson's disease occurred not only in the heart but also in the thyroid.
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