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[Multicentric reticulohistiocytosis: report of a case with systemic disease]
Nathalie Stock1, Stephan Saikali, Jacqueline Chevrant-Breton
1Département d'Anatomie Pathologique, CHU Pontchaillou, 2 rue H. Le Guillou, 35033 Rennes 9.
Abstract:
Multicentric reticulohistiocytosis (RHM) is a rare non Langherhans cell histiocytosis with skin and joint involvment. Nearly all organs can be involved. Association with cancer occurs in about 25% of cases. Association with auto-immune diseases has also been recorded. Microscopic examination shows a histiocytic nodular infiltrate made of giant cells with ground-glass appearance and PAS positive cytoplasm. Immunostaining shows cell positivity for CD68 and negativity for CD1a and S100 protein. No Birbeck granules are found at ultrastructural examination.
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