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Related Experiment Videos

Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis.

C J Willer1, D A Dyment, A D Sadovnick

  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Tissue Antigens
|June 29, 2005
PubMed
Summary

This study found no link between maternal-fetal human leukocyte antigen (HLA) compatibility and multiple sclerosis (MS) risk. Increased HLA compatibility does not appear to influence MS susceptibility in families.

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Area of Science:

  • Immunogenetics
  • Neuroimmunology
  • Human Genetics

Background:

  • Major histocompatibility complex (MHC) compatibility may influence fetal tolerance and viability.
  • Increased maternal-fetal human leukocyte antigen (HLA) class II DR compatibility is linked to scleroderma.
  • The role of maternal-fetal HLA compatibility in multiple sclerosis (MS) risk is unknown.

Purpose of the Study:

  • To investigate the association between maternal-fetal MHC class II DR compatibility and the risk of developing MS.
  • To determine if increased HLA compatibility contributes to MS susceptibility.

Main Methods:

  • Human leukocyte antigen (HLA)-DRB1 typing was conducted on 2170 individuals with MS and 2894 unaffected relatives from 1006 families.
  • Analysis compared HLA compatibility between affected individuals and their mothers versus unaffected individuals and their mothers.

Related Experiment Videos

  • Transmission of HLA alleles from parents to offspring was examined in families with specific parental HLA sharing patterns.

    • Main Results:

    • No evidence of increased maternal-fetal HLA compatibility was found in individuals with MS compared to controls.
    • No significant differences in HLA compatibility were observed between affected individuals and their mothers or fathers.
    • No excess transmission of shared maternal-fetal HLA alleles to affected offspring was detected.

    Conclusions:

    • The findings do not support a role for excess maternal-fetal HLA-DRB1 compatibility in the susceptibility to multiple sclerosis.
    • This study suggests that maternal-fetal HLA compatibility is unlikely to be a significant factor in MS pathogenesis.