Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rho and vascular disease.

Barbara E Rolfe1, Nathalie F Worth, Cameron J World

  • 1Centre for Research in Vascular Biology, School of Biomedical Sciences, University of Queensland, Qld 4072, Australia.

Atherosclerosis
|June 29, 2005
PubMed
Summary

Rho GTPases regulate cellular processes and are implicated in vascular diseases like atherosclerosis. Targeting their adverse signaling pathways may offer new therapeutic strategies for vascular conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preface to the special issue for the 30th International Complement Workshop Brisbane 2025.

Immunobiology·2025
Same author

Dietary modification of membrane composition mimics characteristics of thermal acclimation in the eastern newt (Notophthalmus viridescens).

The Journal of experimental biology·2025
Same author

Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles.

ACS applied bio materials·2022
Same author

Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity.

Journal of medicinal chemistry·2021
Same author

An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer.

Antibodies (Basel, Switzerland)·2021
Same author

Correction to High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by <sup>19</sup>F Magnetic Resonance and Optical Imaging.

ACS nano·2020

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Vascular Biology

Background:

  • Rho family GTPases are key regulators linking cell surface receptors to the actin cytoskeleton.
  • These proteins are crucial for fundamental cellular processes, including vascular functions.

Purpose of the Study:

  • To explore the roles of Rho GTPases in vascular biology.
  • To understand their involvement in atherogenesis and potential therapeutic targeting.

Main Methods:

  • Review of existing literature on Rho GTPase signaling in the vasculature.
  • Analysis of Rho GTPase involvement in cellular processes relevant to vascular health and disease.

Main Results:

  • Rho signalling pathways are involved in endothelial barrier function, inflammation, leukocyte migration, platelet activation, thrombosis, and oxidative stress.

Related Experiment Videos

  • These pathways also regulate smooth muscle cell contraction, migration, proliferation, and differentiation, contributing to atherogenesis.
  • Statins may exert beneficial non-lipid-lowering effects by inhibiting Rho protein activation.
  • Rho proteins can promote endothelial repair and maintain smooth muscle cell differentiation.

    • Conclusions:

    • Rho GTPases play complex, dual roles in vascular health and disease.
    • Further elucidation of Rho effector mechanisms in the vasculature is needed.
    • Targeted therapies focusing on adverse Rho signalling effects hold therapeutic potential for vascular diseases.