Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GnRH in non-hypothalamic reproductive tissues.

N Ramakrishnappa1, R Rajamahendran, Yung-Ming Lin

  • 1Faculty of Agricultural Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4.

Animal Reproduction Science
|June 29, 2005
PubMed
Summary

Gonadotropin releasing hormone (GnRH) regulates mammalian reproduction and acts via specific receptors in reproductive tissues. Research into different GnRH forms and their receptors may lead to targeted therapies for hormone-dependent diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids.

Molecular biology reports·2026
Same author

Penile Hemodynamic Patterns Highlighting the Impact of Diabetes in Young Men With Erectile Dysfunction.

Andrology·2026
Same author

The reduction in total motile sperm count and the increase in sperm DNA fragmentation are associated with paternal age in normozoospermic men.

The aging male : the official journal of the International Society for the Study of the Aging Male·2026
Same author

The investigation of penile hemodynamic profile and relevant hormones in erectile dysfunction patients with non-diabetic chronic kidney disease.

The journal of sexual medicine·2025
Same author

The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.

Andrology·2023
Same author

Author Correction: The mitochondrial genome encodes abundant small noncoding RNAs.

Cell research·2021

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Molecular Endocrinology

Background:

  • Gonadotropin releasing hormone (GnRH) is a key decapeptide regulating mammalian reproduction.
  • GnRH and its analogues are vital in treating hormone-dependent diseases and in assisted reproductive technology.
  • Multiple GnRH forms (GnRH-I, GnRH-II, GnRH-III) exist across species, acting via G protein-coupled receptors.

Purpose of the Study:

  • To explore the diverse roles and mechanisms of GnRH beyond the hypothalamus-pituitary axis.
  • To investigate the presence and function of GnRH and its receptors in extra-hypothalamic reproductive tissues.
  • To understand the implications of different GnRH forms for reproductive health and therapeutic development.

Main Methods:

  • Literature review of studies on GnRH structure, function, and receptor interactions.

Related Experiment Videos

  • Analysis of research on GnRH expression and action in reproductive tissues (ovaries, testes, endometrium, etc.).
  • Examination of cell signaling pathways (PLC, PKA2, PLD, AC) activated by GnRH in target tissues.

    • Main Results:

    • GnRH acts through autocrine/paracrine mechanisms in reproductive tissues, influencing steroidogenesis and apoptosis.
    • GnRH-II is predominantly expressed in extra-pituitary tissues, utilizing distinct signaling pathways.
    • GnRH exhibits both stimulatory and inhibitory effects on steroidogenesis in ovarian and male gonadal tissues.
    • Increased GnRH presence is noted in ovarian, endometrial, and prostate carcinomas.
    • Type-II GnRH receptors are present in various reproductive tissues, suggesting specific roles for GnRH-II.

    Conclusions:

    • GnRH plays significant roles in reproductive tissues beyond the central neuroendocrine control.
    • The distinct forms of GnRH and their receptors offer potential for developing novel, targeted therapeutic analogues.
    • Further research into GnRH variants and cognate receptors is crucial for advancing reproductive medicine and cancer therapy.