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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Systemic lupus erythematosus: the first Italian prevalence study]
M Benucci1, F Li Gobbi, A Del Rosso
1Sezione di Reumatologia Nuovo Ospedale S. Giovanni di Dio, Via di Torregalli 3, Florence, Italy. maubenucci@tiscali.it
Objectives:
The aim of the study was the assessment of SLE prevalence in an adult population. The study was performed on a sample of more than 30,000 patients over 18 resident in the Florence sub-area of Scandicci-Le Signe (Italy) on the basis of the register of general practitioners (GPs).
Methods:
Twenty GPs gave the Lupus Screening Questionnaire (LQS) to their patients. The LQS has been completed by 32,521 patients resident in Scandicci, Lastra a Signa and Signa area. On the basis of the LQS analysis an SLE diagnosis was suspected in 30 patients. These 30 patients have been investigated by routine exams, anti-nuclear antibodies and have been referred to rheumatologist to assess the SLE diagnosis and disease activity (ECLAM Score).
Results:
The overall population aged >18 years was 71,204 (42,474 living in Scandicci, 15,368 in Lastra a Signa and 13,362 in Signa). The diagnosis was confirmed in 23 out of the 30 suspected SLE patients. Eleven out of the 23 SLE patients were from Scandicci, 6 from Lastra a Signa and the other 6 from Signa. The overall rate of SLE prevalence is 71/100,000 (1 case/1,408) with a confidence interval of 95%, (confidence limits: 49-92). The rate of SLE prevalence in Scandicci is 81/100,000 (confidence limits: 42-121), in Lastra a Signa 62/100,000 (confidence limits: 32-92) and in Signa 65/100,000 (confidence limits: 36-94).
Conclusion:
This is the first epidemiological study on SLE prevalence in Italy. The rate of SLE prevalence is similar to that of other European studies. LQS is confirmed as an easy and reliable tool to assess SLE diagnosis also in the Italian population.