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Related Experiment Videos

Methylphenidate increases cigarette smoking.

Craig R Rush1, Stephen T Higgins, Andrea R Vansickel

  • 1Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.

Psychopharmacology
|June 29, 2005
PubMed
Summary
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Methylphenidate (Ritalin) increases cigarette smoking rates in adults without ADHD. This stimulant medication dose-dependently increased smoking behavior, similar to d-amphetamine.

Area of Science:

  • Pharmacology
  • Behavioral Science

Background:

  • Methylphenidate (Ritalin) and d-amphetamine (Dexedrine) are commonly prescribed stimulants for attention deficit hyperactivity disorder (ADHD).
  • Previous research indicates d-amphetamine increases smoking rates and reinforcement.
  • The impact of methylphenidate on smoking behavior remains under-assessed, despite ADHD individuals' heightened smoking risk.

Purpose of the Study:

  • To investigate the acute effects of various methylphenidate doses on cigarette smoking in non-ADHD adult smokers.
  • To compare the effects of methylphenidate with placebo on smoking behavior.

Main Methods:

  • Ten adult cigarette smokers (without ADHD or psychiatric disorders) participated.
  • Participants received placebo or one of four methylphenidate doses (5, 10, 20, 40 mg).

Related Experiment Videos

  • Smoking behavior (cigarettes smoked, puffs, latency, carbon monoxide) and caloric intake were measured over 4 hours post-ingestion.

    • Main Results:

    • Methylphenidate demonstrated a dose-dependent increase in the number of cigarettes smoked, total puffs, and carbon monoxide levels.
    • Concurrently, methylphenidate led to a dose-dependent decrease in food consumption and caloric intake.
    • These findings suggest a direct impact of methylphenidate on smoking behavior.

    Conclusions:

    • Methylphenidate, similar to d-amphetamine, appears to increase cigarette smoking rates.
    • The study highlights a potential link between methylphenidate use and increased smoking behavior.
    • Further research is warranted to explore this relationship in clinical populations.