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High-throughput photometric titrimetry based on a feedback-based and subsequent fixed triangular wave-controlled flow

Hideji Tanaka1, Tsutomu Baba

  • 1Institute of Health Biosciences, Tokushima University, Shomachi 1-78-1, Tokushima 770-8505, Japan. htanaka@ph.tokushima-u.ac.jp

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|June 30, 2005
PubMed
Summary

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Flow ratiometry enables high-throughput photometric titration by controlling reagent flow rates. This method achieves rapid analysis (1.76 seconds per titration) with high precision, advancing automated chemical analysis.

Area of Science:

  • Analytical Chemistry
  • Chemical Engineering

Background:

  • Flow ratiometry was previously established for potentiometric titration.
  • High-throughput analytical methods are crucial for modern chemical analysis.

Purpose of the Study:

  • To extend the principle of flow ratiometry to photometric titration.
  • To develop a high-throughput photometric titration method with enhanced speed and precision.

Main Methods:

  • Linear variation of base solution flow rate (FB) controlled by voltage (Vc).
  • Constant total flow rate (FT) with acid and base solutions merging.
  • Measurement of relative transmittance at the indicator's absorption maximum.
  • Feedback control and limited scan range (triangular waves) around the equivalence point (EP).

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Main Results:

  • Achieved a maximum throughput of 34 titrations per minute (1.76 seconds per titration).
  • Maintained reasonable precision with relative standard deviation (RSD) below 0.5%.

Conclusions:

  • Flow ratiometry is effectively extended to photometric titration.
  • The developed method offers unprecedented throughput for automated titrations.
  • This technique significantly enhances the speed of chemical analysis without compromising precision.