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Related Experiment Videos

Desferrioxamine release from gelatin-based systems.

Kezban Ulubayram1, Aysel Kiziltay, Elvan Yilmaz

  • 1Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey.

Biotechnology and Applied Biochemistry
|June 30, 2005
PubMed
Summary
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Gelatin microspheres and films were developed as controlled-release systems for desferrioxamine (DFO) to improve thalassaemia treatment. These novel drug delivery systems offer potential for long-term iron chelation therapy, enhancing patient compliance.

Area of Science:

  • Biomaterials Science
  • Pharmaceutics
  • Drug Delivery Systems

Background:

  • Conventional treatment for thalassaemia involves regular red-blood-cell transfusions and iron chelation with desferrioxamine (DFO).
  • Desferrioxamine (DFO) has drawbacks including poor oral bioavailability, toxicity, short half-life, and requires frequent, uncomfortable subcutaneous infusions, leading to poor patient compliance.
  • Controlled-release systems offer a potential alternative to improve supportive treatment for thalassaemia.

Purpose of the Study:

  • To develop and evaluate gelatin microspheres (GMs) and gelatin films (GFs) as controlled-release systems for desferrioxamine (DFO).
  • To assess the stability and drug release characteristics of these gelatin-based matrices.
  • To investigate the mechanical properties of the developed gelatin films.

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Main Methods:

  • Gelatin microspheres (GMs) were prepared using coacervation and gelatin films (GFs) using casting methods.
  • Cross-linking of gelatin matrices was performed using glutaraldehyde and carbodiimide to enhance stability.
  • In vitro release of DFO from microspheres and films was quantified over time; mechanical properties of films were tested.

Main Results:

  • Uncross-linked gelatin matrices degraded within 4 hours, while cross-linking extended degradation to weeks.
  • DFO release from microspheres over 7 days ranged from 12-82%, and permeation through films in 5 hours ranged from 34-67%.
  • Gelatin films exhibited good mechanical properties, with tensile strength (0.14-0.69 MPa), elastic modulus (0.12-1.29 MPa), and strain at break (26.49-109.38%).

Conclusions:

  • Gelatin-based controlled-release systems (GMs and GFs) can be effectively prepared for desferrioxamine (DFO) delivery.
  • Cross-linking significantly improves the stability of these gelatin matrices, enabling controlled drug release over extended periods.
  • Developed gelatin systems show promise as candidates for long-term DFO-carrying systems, potentially improving thalassaemia management.