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Related Experiment Videos

Alternatively spliced human genes by exon skipping--a database (ASHESdb).

Meena Kishore Sakharkar1, Bagavathi S Perumal, Yun Ping Lim

  • 1Nanyang Centre for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798. mmeena@ntu.edu.sg

In Silico Biology
|June 30, 2005
PubMed
Summary

Researchers identified 1,229 human genes with alternative splicing via exon skipping. This process allows single coding sequences to generate diverse gene products, expanding functional capabilities.

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Area of Science:

  • Molecular Biology
  • Genomics

Background:

  • Alternative splicing of messenger RNA (mRNA) enables diverse protein functions from one gene.
  • Exon skipping is a primary mechanism of alternative splicing.

Purpose of the Study:

  • To create a comprehensive database of alternative splicing by exon skipping for human genome data.
  • To identify human genes exhibiting alternative splicing via exon skipping.

Main Methods:

  • Analysis of human genome data.
  • Identification and cataloging of alternative splicing events, specifically exon skipping.

Main Results:

  • A database of alternative splicing by exon skipping has been compiled.
  • 1,229 human genes were identified as utilizing alternative splicing through exon skipping.

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Conclusions:

  • Alternative splicing, particularly exon skipping, is a significant mechanism for generating proteomic diversity in the human genome.
  • The established database provides a valuable resource for studying gene regulation and function.