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Related Experiment Videos

Possible azithromycin-associated hiccups.

F Jover1, J M Cuadrado, J Merino

  • 1Department of Internal Medicine, Infectious Diseases Division, Hospital of San Juan, Alicante, Spain. fjoverdiaz@coma.es

Journal of Clinical Pharmacy and Therapeutics
|June 30, 2005
PubMed
Summary
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Azithromycin, an antibiotic, can rarely cause persistent hiccups. This case report suggests a possible vagal mechanism for this rare side effect, emphasizing careful diagnosis of drug-induced hiccups.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Clinical Case Reports

Background:

  • Drug-induced hiccups are a rare adverse effect.
  • Macrolide antimicrobials are infrequently associated with hiccups.

Observation:

  • A 76-year-old male developed persistent, exhausting hiccups after initiating azithromycin for pharyngitis.
  • Extensive investigations ruled out other organic causes for the hiccups.

Findings:

  • Discontinuation of azithromycin and subsequent baclofen treatment resolved the hiccups.
  • The event was classified as a possible adverse drug reaction using the Naranjo scale.
  • A vagal mechanism mediated by azithromycin is hypothesized as the cause.

Implications:

Related Experiment Videos

  • Diagnosis of drug-induced hiccups requires a process of elimination.
  • This case highlights a potential, albeit uncommon, side effect of azithromycin.
  • Further research into the vagal mechanisms of macrolide-induced hiccups is warranted.