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Gallbladder carcinosarcoma: a case report and literature review.
Kevin L Huguet1, Christopher B Hughes, Winston R Hewitt
1Department of Transplantation, Mayo Clinic, Jacksonville, Florida 32224, USA.
Summary
Carcinosarcoma of the gallbladder is a rare and aggressive cancer. This case highlights the complex surgical management and pathological findings of this unusual malignancy.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Gallbladder carcinosarcoma is an exceptionally rare malignancy, comprising both epithelial and mesenchymal elements.
- This tumor exhibits highly aggressive clinical behavior, with limited documented cases worldwide.
Observation:
- A 64-year-old woman presented with fever and a right upper quadrant mass.
- Initial assessment suggested severe cholecystitis; however, CT revealed a large pericholecystic mass involving the colon.
Findings:
- The patient underwent extensive surgery including cholecystectomy, hepatic wedge resection, pancreaticoduodenectomy, and right hemicolectomy.
- Pathological examination confirmed gallbladder carcinosarcoma, with squamous cell carcinoma and spindle cell sarcoma components.
- All examined lymph nodes were negative for malignancy.
Implications:
- This case underscores the diagnostic and surgical challenges posed by gallbladder carcinosarcoma.
- It contributes to the limited literature, informing treatment strategies and prognosis for this rare cancer.