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Updated: Aug 9, 2026

Nuclear Transfer into Mouse Oocytes
Published on: November 30, 2006
[Mechanisms of epigenetic reprogramming in Mammalian resonstructed embryos produced by nuclear transfer.]
Shi-Jing Xu1, Yin-Xue Xu, Hong-Lin Liu
1College of Animal Science, Nanjing Agricultural University, Nanjing 210095, China,
Abstract:
Circumstantial studies indicated that incomplete or inappropriate epigenetic reprogramming of donor nuclei was likely to be the primary reason for failures in nuclear transfer. In this view, we discussed the roles of several epigenetic mechanisms, including DNA methylation, chromatin remodeling, imprinting and X chromosome inactivation, telomere maintenance, and epigenetic inheritance in the observed abnormalities in clones from different species. Understanding the mechanisms underlying epigenetic reprogramming control will help us resolve the inherent problems in nuclear transfer technology and make its applications promising.
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