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Related Experiment Videos

A new screening tool for cervical dystonia.

R Saunders-Pullman1, J Soto-Valencia, C Costan-Toth

  • 1Department of Neurology, Beth Israel Medical Center, 10 Union Square E., Suite 5J, PACC, New York, NY 10003, USA. rsaunder@bethisraelny.org

Neurology
|June 30, 2005
PubMed
Summary

The Beth Israel Dystonia Screen (BIDS) effectively identifies cervical dystonia using a telephone interview. This tool shows high sensitivity and specificity, aiding in genetic and epidemiologic studies.

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Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Dystonia family studies face challenges due to small family size and incomplete ascertainment.
  • Prevalence estimates for dystonia are likely underestimated, as many cases are clinic-based or misdiagnosed.
  • A need exists for a sensitive, low-cost screening tool to improve dystonia case detection.

Purpose of the Study:

  • To assess the validity and utility of the Beth Israel Dystonia Screen (BIDS), a computer-assisted telephone interview, for screening cervical dystonia.

Main Methods:

  • The BIDS was administered to 193 individuals from 16 families with cervical and cranial dystonia.
  • Videotaped neurologic examinations were conducted for all participants.
  • The predictive value of BIDS questions was evaluated against a gold standard of definite dystonia determined by video review.

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Main Results:

  • A positive response to at least two of five BIDS questions yielded 100% sensitivity and 92% specificity for cervical dystonia.
  • Using three or more positive questions identified definite dystonia with 81% sensitivity and 97% specificity.

Conclusions:

  • The Beth Israel Dystonia Screen (BIDS) demonstrates excellent sensitivity and specificity for identifying cervical dystonia in family-based samples.
  • The BIDS is recommended for family studies, with cross-validation in population samples advised for epidemiologic research.